Resuscitation Outcomes Consortium (ROC)

The mission of the Resuscitation Outcomes Consortium (ROC) is to provide
infrastructure and project support for clinical trials and other
outcome-oriented research in the areas of cardiopulmonary arrest and severe
traumatic injury that will rapidly lead to evidence-based change in clinical
practice. The focus on pre-hospital and early hospitalization interventions
recognizes the critical importance of this time frame and early congruence
between the emergency cardiac and trauma populations. ROC Investigators will
conduct collaborative trials of variable size and duration (equally directed
towards the cardiac and trauma populations), leveraging the combined power of
the member institutions and promoting the rapid translation of promising
scientific and clinical advances for the public good

ROC is funded by the National Heart Lung and Blood Institute, the American Heart Association, US Army Medical Research & Materiel Command, Institutes of Health Research (Canada), Heart & Stroke Foundation of Canada, and Defense R&D Canada. Learn more.

Upcoming Studies

Continuous Chest Compressions.  This proposed study, open for public comment, will compare two techniques for performing CPR: 30 compressions:2 ventilations versus continuous chest compressions (no interruptions).  Learn more.

Current Studies

Prehospital Lactate.  This study tests whether blood lactate levels in injured patients in an ambulance predicts the need for emergency surgery, blood transfusions or other complications.  Lactate will be measured in a drop of blood from patients who are being taken to a trauma center by ambulances.  The drop of blood will be taken from the needles used to start an intravenous line.  Only patients who are already getting an intravenous line will be tested.  Paramedics will put the drop of blood on a test strip that measures lactate. There is no change in patient care, no extra blood drawn, and no change in treatment at the hospital. Most patients will have lactate measured again at the hospital to compare with the results from the paramedic device.  Investigators will track what happens to subjects by reviewing the ambulance and hospital records.

Completed Studies

Hypertonic Saline for Traumatic Brain Injury. This study examined whether patients who were unconscious after a traumatic head injury would have better outcomes when a concentrated salt solution was used by paramedics as the initial intravenous fluid.

Hypertonic Saline Resuscitation for Severe Trauma.  This study examined whether patients with low blood pressure after severe injury would have better outcome when a concentrated salt solution was used by paramedics as the initial intravenous fluid.

Real-time CPR Feedback for Cardiac Arrest.  This study examined whether a device that measured and provided feedback on CPR to paramedics would improve delivery of CPR and result in better patient survival

ROC-PRIMED. This study examined whether a strategy of rescue shocks as soon as possible after arrival or a strategy of doing 3 minutes of CPR before rescue shocks improved survival after cardiac arrest.A separate component of the study examined whether using a device that decreased pressure in the chest during CPR would improve survival