PCAS Publications

Current Studies

PCAS recruits subjects for observational studies and trials during their clinical care.  

COMICA (Characterization of Mitochondrial Injury after Cardiac Arrest) is a study sponsored by NIH through the CTSA network.  This study partners our department with three other university programs - Virginia Commonwealth University, University of Pennsylvania and Beth Israel - Deaconess (Harvard University).  Subjects provide blood samples and detailed clinical information for a multicenter database and tissue repository.  Initial studies will examine biological markers of mitochondrial stress that are expected to occur after ischemia-reperfusion associated with cardiac arrest.

Safety and Pharamacokinetics of Levetiracetam in Post-Arrest Patients is a single-arm trial of the intravenous anticonvulsant levetiracetam to suppress seizures which are common during the first few days after cardiac arrest.

Functional Outcomes II is a trial of the effectiveness of the "Maximizing Energy (MAX)" intervention for reducing the severity of fatigue and improving performance and participation in daily activities in patients during the months after cardiac arrest.

Previous Studies

Studies about systems for post-cardiac arrest care

Rittenberger JC, Guyette FX, Tisherman SA, DeVita MA, Alvarez RJ, Callaway CW. Outcomes of a hospital-wide plan to improve care of comatose survivors of cardiac arrest.  Resuscitation. 2008; 79: 198-204.

Donnino MW, Rittenberger JC, Gaieski D, Cocchi MN, Giberson B, Peberdy MA, Abella BS, Bobrow BJ, Callaway C.  The development and implementation of cardiac arrest centers.  Resuscitation. 2011 Mar 29. [Epub ahead of print]

Martin-Gill C, Dilger CP, Guyette FX, Rittenberger JC, Callaway CW.  Regional Impact of Cardiac Arrest Center Criteria on Out-of-Hospital Transportation Practices.  Prehosp Emerg Care. 2011; 15: 381-387. 

Studies about post-cardiac arrest illness

Reynolds JC, Callaway CW, El Khoudary SR, Moore CG, Alvarez RJ, Rittenberger JC. Coronary angiography predicts improved outcome following cardiac arrest: propensity-adjusted analysis.  J Intensive Care Med. 2009; 24: 179-178

Rittenberger JC, Raina K, Holm MB, Kim YJ, Callaway CW. Association between Cerebral Performance Category, Modified Rankin Scale, and discharge disposition after cardiac arrest.  Resuscitation. 2011 Apr 13. [Epub ahead of print]

Raina KD, Callaway C, Rittenberger JC, Holm MB.  Neurological and functional status following cardiac arrest: method and tool utility.  Resuscitation. 2008; 79: 249-256.

Studies about neurological recovery

Rittenberger JC, Popescu A, Brenner RP, Guyette FX, Callaway CW.  Frequency and Timing of Nonconvulsive Status Epilepticus in Comatose Post-Cardiac Arrest Subjects Treated with Hypothermia.  Neurocrit Care. 2011 Jun 3. [Epub ahead of print]  PMID: 21638118

Metter RB, Rittenberger JC, Guyette FX, Callaway CW. Association between a quantitative CT scan measure of brain edema and outcome after cardiac arrest. Resuscitation. 2011 Apr 12. [Epub ahead of print] PMID: 21592642

Rittenberger JC, Sangl J, Wheeler M, Guyette FX, Callaway CW.  Association between clinical examination and outcome after cardiac arrest.  Resuscitation. 2010; 81: 1128-1132. 

Neuroimaging of Comatose Post-Arrest Patients is an observational study to collect specialized MRI studies in patients with persistent coma at early time points after cardiac arrest.