Clinical Trials in Emergency Medicine

The Department of Emergency Medicine participates in multiple clinical trial networks and also conducts local investigator-initiated clinical trials.  Research specialists support enrollment in these trials in the emergency department and by coordinating with emergency medical services. 

SIREN (Strategies to Innovate Emergency Care Clincal Trial Network) is a jointly NINDS-NHLBI supported network dedicated to testing interventions for brain, heart, lung or blood emergencies.  SIREN is a continuation of both the Resusciation Outcomes Consortium (NHLBI) and the Neurological Emergencies Treatment Trial network (NINDS).  Current trials in include:

  • BOOST-3 is testing intracranial pressure monitoring versus brain tissue oxygen monitoring to guide intensive care in severe traumatic brain injury

PETAL (Prevention & Early Treatment of Acute Lung Injury) is an NHLBI supported network dedicated to testing early treatments for acute lung injury.  Current trials include:

  • CLOVERS (Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis) is testing two approaches to treatment of sepsis: early initiation of vaopressor drugs versus early large volume fluid resuscitation.

LITES (Linking Investigations in Trauma and Emergency Services) is a Department of Defense supported network dedicated to testing emergency treatment for traumatic injury. Current trials include:

  • Study of whole blood versus blood component therapy in resuscitation of severe trauma with hemorrhagic shock

MATCH (Mechanisms for Alcohol Treatment Change)

  • A trial comparing components of a text message intervention to reduce hazardous drinking among young adults and to determine the mechanisms through which these changes occur.

Post-Cardiac Arrest Research.  Our post-arrest service enrolls subjects in several clinical trials